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Tag Archives: systemic lupus erythematosus signs and symptoms

Systemic Lupus Erythematosus (SLE)/Lupus- Etiology Causes, SLE Cause

Systemic Lupus Erythematosus (SLE)/Lupus- Etiology (Cause’s) – Dr. Ashish Badika

Systemic Lupus Erythematosus (SLE)/Lupus is an autoimmune disease. The immune system of a person attacks its own tissues which it identifies as foreign ones.

There is no specific known cause why our own body’s army (immune system) gets confused and starts attacking itself. The cause of SLE remains unknown and is definitely multifactorial. Many observations suggest a role for genetic, hormonal, immunologic, and environmental factors. 

Lupus develops in response to a combination of factors like:

  1. Genetics: – Researchers say there is around 50 genes likely to contribute to it’s Lupus. There is no evidence to suggest that they directly cause Lupus.
  2. Environmental factors: –
  • Several Viruses  like EBV.
  • bacterial infections may trigger increased immune activation and inflammation.
  • Exposure to ultraviolet light.

3. Hormonal: – Most of the cases of Lupus are females. Differences in our hormones — chemical messengers that deliver messages from the brain to the body may play a role in this. Studies show that estrogen contributes to the development of lupus and makes it more severe.

4. Immune abnormalities: – There are various immune defects in patients with Lupus. Clinical manifestations are mediated directly or indirectly by antibody formation and the creation of immune complexes (IC).

One can still get Lupus without having a family history of a single person with Lupus symptoms.

Dr. Ashish K Badika has 3 years of advanced training in Rheumatology and Clinical Immunology including 2 years Post Doctoral.

He has extensive exposure to Systemic Autoimmune Disorder (Rheumatoid arthritis, Psoriatic arthritis, Seronegative spondyloarthritis, Systemic lupus erythematosus, Scleroderma, Gout, Myositis, Sjogren’s Syndrome, Vasculitic conditions, and Paediatric rheumatology disorders).

Systemic Lupus Erythematosus (SLE)/ Lupus, SLE Symptoms

Systemic Lupus Erythematosus (SLE)/ Lupus – Symptoms – Dr. Ashish Badika

In Systemic Lupus Erythematosus (SLE) or also call as LUPUS our own body’s immune system starts to damage the organs and tissues of our own body. This is what is called autoimmunity.

Symptoms of SLE are so different in different people that no two cases are alike. This makes it hard to diagnose at the beginning. Patients with SLE may have pain and swelling in joints very frequently. Some develop in arthritis with the passage of time.

SLE affects many organs of the body.

  • Heart: Valve problems, risk of heart attacks increases.
  • Brain and nervous system: Headaches, tingling, strokes or seizures, eye problems, weakness, numbness, memory and personality changes, and difficulty in expressing their thoughts.
  • Digestive tract: Abdominal pain, nausea, and vomiting
  • Lung : Bleeding into lungs and pneumonia, difficulty breathing, coughing up blood
  • Skin: recurrent oral ulcers
  • Kidney: Swelling in the legs, kidney failure is one of the leading causes of death among people with lupus.
  • Circulation: Clots in veins or arteries, constriction or inflammation of blood vessels, anaemia, low white blood cell or platelet count.

Some common symptoms are listed below:

  • Weight loss.
  • Painful areas in the mouth and gum (canker sores)
  • Chest pains when you take a deep breath also called as pleuritis
  • Swollen lymph nodes.
  • Prolonged Fever on and off.
  • General discomfort, uneasiness, or ill feeling (malaise).
  • Hair loss.
  • Recurrent miscarriage
  • High blood pressure during pregnancy
  • Filling of water around the heart and lungs, causing difficulty in breathing
  • Sunlight sensitivity also called as photosensitivity. It gets worse in sunlight.
  • Skin rash — Malar rash develops with SLE. The rash is spreads around cheeks and the nose in shape of a butterfly.

SLE/LUPUS may present in several ways. Meet a Rheumatologist if you are facing these issues.

Dr. Ashish K Badika has 3 years of advanced training in Rheumatology and Clinical Immunology including 2 years Post Doctoral.

He has extensive exposure to Systemic Autoimmune Disorder (Rheumatoid arthritis, Psoriatic arthritis, Seronegative spondyloarthritis, Systemic lupus erythematosus, Scleroderma, Gout, Myositis, Sjogren’s Syndrome, Vasculitic conditions, and Paediatric rheumatology disorders).